Pathogenic bacteria that resist nearly all antibiotics are continuing to spread worldwide, the human population is getting sicker, and experts
In autologous cell therapy, the patient’s own cells are cultured, genetically engineered and expanded outside the body in small, individual batches, bespoke to each patient, before being reintroduced into the body, for example to attack a tumour. This therapeutic approach places new demands on the manufacturing equipment needed to deliver this product. With traditional biologics, one scales up the liquid volume of the equipment to increase production capacity. Such systems are relatively simple to engineer for reliability and subsequently qualify through testing. With autologous cell products, production capacity is generally scaled up by increasing the number of manufacturing systems. This presents new challenges for manufacturing reliability because of the large number of systems, a high total part count and resulting challenges in system qualification. Given that reduced reliability and lost production runs are not an option in autologous cell therapy, what can therapy developers do to address this challenge?
Part 3: What is the yield of genetic transformation? Genetic engineering of CAR T-cells for therapeutic applications is going through
In the beginning… In the 1970s, with the advancement in semiconductor microelectronics, researchers such as John Greenwood worked on wet
Anyone even remotely linked to the field of Molecular Biology will have noticed the escalation in use of the CRISPR-Cas9
In a world dominated by computers it is still a challenge for electronics to interact with the molecules that control
Despite researchers’ best efforts, a definite cure has yet to be found for either Parkinson’s or Alzheimer’s disease. Over the
Global antibiotic resistance is a threat to our very existence. We need ingenious ways to discover new bug-defeating drugs, and
The benefits of preventive medicine and treating early are well known and a cornerstone of the current UK healthcare system¹.
Diagnose, locate & treat. Earlier, easier & safer. This is the golden age of medicine, nanomedicine. Colloidal gold holds the